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Open Access Highly Accessed Review

Mesenchymal stem cell-educated macrophages

Elke Eggenhofer1* and Martin J Hoogduijn2

Author Affiliations

1 Department of Surgery, University Medical Center of Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany

2 Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Transplantation Research 2012, 1:12  doi:10.1186/2047-1440-1-12

Published: 28 September 2012

Abstract

Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.